Cheap Flights from Rome to Panama City

Compare Rome to Panama City flight deals

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Flight deals from Rome to Panama City

Looking for a cheap last-minute deal or the best return flight from Rome to Panama City? If you want to travel next month, return fares start from $1,138. Find the lowest prices on one-way and return tickets right here.

Panama City.$1,138 per passenger.Departing Sun, 12 Apr, returning Sat, 25 Apr.Return flight with Turkish Airlines.Outbound indirect flight with Turkish Airlines, departs from Rome Fiumicino on Sun, 12 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Turkish Airlines, departs from Panama City Tocumen International on Sat, 25 Apr, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,138, select.

Panama City.$1,174 per passenger.Departing Fri, 27 Mar, returning Sat, 4 Apr.Return flight with Turkish Airlines.Outbound indirect flight with Turkish Airlines, departs from Rome Fiumicino on Fri, 27 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Turkish Airlines, departs from Panama City Tocumen International on Sat, 4 Apr, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,174, select.

Panama City.$1,174 per passenger.Departing Wed, 6 May, returning Sat, 9 May.Return flight with Turkish Airlines.Outbound indirect flight with Turkish Airlines, departs from Rome Fiumicino on Wed, 6 May, arriving in Panama City Tocumen International.Inbound indirect flight with Turkish Airlines, departs from Panama City Tocumen International on Sat, 9 May, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,174, select.

Panama City.$1,174 per passenger.Departing Wed, 22 Apr, returning Wed, 6 May.Return flight with Turkish Airlines.Outbound indirect flight with Turkish Airlines, departs from Rome Fiumicino on Wed, 22 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Turkish Airlines, departs from Panama City Tocumen International on Wed, 6 May, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,174, select.

Panama City.$1,220 per passenger.Departing Mon, 22 Jun, returning Thu, 2 Jul.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Mon, 22 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Thu, 2 Jul, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,220, select.

Panama City.$1,241 per passenger.Departing Sun, 14 Jun, returning Sun, 21 Jun.Return flight with Iberia.Outbound indirect flight with Iberia, departs from Rome Fiumicino on Sun, 14 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Iberia, departs from Panama City Tocumen International on Sun, 21 Jun, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,241, select.

Panama City.$1,261 per passenger.Departing Thu, 19 Nov, returning Sat, 28 Nov.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Thu, 19 Nov, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Sat, 28 Nov, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,261, select.

Panama City.$1,261 per passenger.Departing Mon, 1 Feb, returning Wed, 10 Feb.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Mon, 1 Feb, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Wed, 10 Feb, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,261, select.

Panama City.$1,261 per passenger.Departing Thu, 17 Sep, returning Thu, 24 Sep.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Thu, 17 Sep, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Thu, 24 Sep, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,261, select.

Panama City.$1,280 per passenger.Departing Mon, 16 Nov, returning Sun, 6 Dec.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Mon, 16 Nov, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Sun, 6 Dec, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,280, select.

Panama City.$1,282 per passenger.Departing Tue, 23 Feb, returning Wed, 3 Mar.Return flight with Iberia.Outbound indirect flight with Iberia, departs from Rome Fiumicino on Tue, 23 Feb, arriving in Panama City Tocumen International.Inbound indirect flight with Iberia, departs from Panama City Tocumen International on Wed, 3 Mar, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,282, select.

Panama City.$1,294 per passenger.Departing Wed, 21 Oct, returning Wed, 28 Oct.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Wed, 21 Oct, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Wed, 28 Oct, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,294, select.

Panama City.$1,314 per passenger.Departing Mon, 1 Jun, returning Tue, 1 Dec.Return flight with KLM and Air France.Outbound indirect flight with KLM, departs from Rome Fiumicino on Mon, 1 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Air France, departs from Panama City Tocumen International on Tue, 1 Dec, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,314, select.

Panama City.$1,316 per passenger.Departing Sun, 31 May, returning Mon, 8 Jun.Return flight with KLM and Air France.Outbound indirect flight with KLM, departs from Rome Fiumicino on Sun, 31 May, arriving in Panama City Tocumen International.Inbound indirect flight with Air France, departs from Panama City Tocumen International on Mon, 8 Jun, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,316, select.

Panama City.$1,353 per passenger.Departing Tue, 20 Oct, returning Tue, 3 Nov.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Rome Fiumicino on Tue, 20 Oct, arriving in Panama City Tocumen International.Inbound indirect flight with Air Europa, departs from Panama City Tocumen International on Tue, 3 Nov, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,353, select.

Panama City.$1,378 per passenger.Departing Tue, 19 Jan, returning Wed, 3 Feb.Return flight with Delta.Outbound indirect flight with Delta, departs from Rome Fiumicino on Tue, 19 Jan, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Wed, 3 Feb, arriving in Rome Fiumicino.Price includes taxes and charges.From $1,378, select.

Find the cheapest month to fly from Rome to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Rome to Panama City flights are currently cheapest in April.

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Alternative Rome to Panama City routes

Looking for the cheapest, fastest or easiest route from Rome to Panama City? You could fly into the following airports instead.

Rome to Panama City: Flight information

The things to know before you go.

Cheapest flight found	$1,138
Cheapest month to fly	April

Check out these Panama City hotels

Ready to plan your stay? Other travellers rate these Panama City hotels for cleanliness, service and location.

Eden`s Garden Hostel

1.64 km from city centre

$71

Per night

Yoo Apartamento

2.05 km from city centre

$241

Per night

Sofitel Legend Casco Viejo - Panama City

4.98 km from city centre

$791

Per night

Eden`s Garden Hostel

1.64 km from city centre

$71

Per night

Yoo Apartamento

2.05 km from city centre

$241

Per night

Sofitel Legend Casco Viejo - Panama City

4.98 km from city centre

$791

Per night

Explore top-rated hotels

Finding cheap flights from Rome to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from Rome to Panama City?

The best price we found for a return flight from Rome to Panama City is $1,138. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Rome to Panama City?

Currently, there are no airlines that fly direct from Rome to Panama City. But we found flights with one or more stops from $1,138.

How many flights are there a week from Rome to Panama City?

As of March 2026, there are no flights flying from Rome to Panama City.

When is the cheapest time to fly from Rome to Panama City?

The cheapest month to fly from Rome to Panama City is usually April.

Which is the cheapest airport to fly into in Panama City?

If you're flying from Rome, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from $1,138.

Which upcoming date is cheapest to fly from Rome to Panama City on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Rome to Panama City on Sunday, 12 April 2026.

Can I get a direct flight from Rome to Panama City?

No airlines currently offer direct flights between Rome and Panama City. Most routes have one or more stops.

How can I get the best flight deal from Rome to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In March, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.

Which is the cheapest airline to fly from Rome to Panama City with?

The cheapest airline that flies to Panama City is Turkish Airlines .

Travelling from Rome to Panama City: what you need to know

Rome is home to a couple of airports where you can kick off your trip. Explore your options for booking a flight from Rome to Panama City leaving from Leonardo da Vinci-Fiumicino Airport (FCO) or Ciampino-G. B. Pastine International Airport (CIA).
Hop off your plane in Panama City at Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB).
Panama City is six hours behind Rome and follows the UTC-5 timezone.
To ensure you get on your Rome to Panama City flight, leave enough time to check in and find your gate. Turning up two hours before international departures and an hour before domestic flights is the general rule.
During popular months such as August, you'll want to get to the airport earlier than usual. Arrive two hours before domestic departures and four hours ahead for an international flight when you fly during high season in general.

How to find the cheapest flights from Rome to Panama City

Booking in advance is often the key to scoring a cheap Rome to Panama City flight. Flight prices rise as demand increases, so the nearer your departure date, the more it could cost you.
If you're flexible with your trip dates, use the 'Whole month' tool. It'll give you the cheapest price across the month when looking for your plane ticket from Rome to Panama City.
Finding a cheap flight from Rome to Panama City is easy with Price Alerts. All you need to do is set up one of these automatic alerts and we'll get in touch when there's a better deal.
Pick your ideal departure and arrival times, number of stops and airlines with the filters. Alternatively, sort your Rome to Panama City flight results by 'Fastest,' 'Cheapest' or 'Best.'

Flying from Rome

Leonardo da Vinci-Fiumicino Airport (FCO)

Consider adding a stopover to possibly find a cheaper Rome to Panama City flight. Just deselect 'Direct flights only' when searching for departures from Leonardo da Vinci-Fiumicino Airport. Take a pause at one of these airports:
- Amsterdam Airport Schiphol (AMS)
- Charles de Gaulle Airport (CDG)
- Adolfo Suarez Madrid-Barajas Airport (MAD)
Travelling from central Rome to FCO takes about 50 minutes by public transport. If you ride-share, drive or take a cab, you'll cover the 23 kilometres in 40 minutes or so, depending on traffic.
After a relaxed start to your holiday? Stay near Leonardo da Vinci-Fiumicino Airport. Whether you're boarding an early flight from Rome to Panama City or want to avoid feeling rushed, these hotels are perfect:
Of the flights that depart from Leonardo da Vinci-Fiumicino Airport, 70.57% land on schedule at their destination.

Ciampino-G. B. Pastine International Airport (CIA)

You can get to CIA from the centre of Rome in about 40 minutes by car, depending on traffic conditions. The journey by public transport takes roughly 1 hour 40 minutes to cover the 13 kilometres or so.
Want to treat yourself to an extra night away before boarding your flight from Rome to Panama City? Relax in a hotel near Ciampino-G. B. Pastine International Airport before your adventure officially starts. These stays are calling your name:
When it comes to keeping flights on track, Ciampino-G. B. Pastine International Airport has an on-time arrival rate of 73%.

Arriving in Panama City

Tocumen International Airport (PTY)

Tocumen International Airport (PTY) to central Panama City takes about 20 minutes by car. The centre is roughly 16 kilometres away.
It usually takes 1 hour 5 minutes to get there when travelling by public transport.
The last thing you need is a lengthy journey to your hotel if you're getting in late on a flight from Rome to Panama City. Stay at one of these accommodation options near PTY instead:
Pick up a Tocumen International Airport rental car and discover Panama City and beyond with your own set of wheels. Avis, Dollar and MEX are popular providers to choose from here.
To get the lowest price, book your ride from Tocumen International Airport about three weeks in advance of your Rome to Panama City flight.

Marcos A. Gelabert International Airport (PAC)

Central Panama City is about 2 kilometres from Marcos A. Gelabert International Airport (PAC). After your flight from Rome to Panama City has touched down and you've made your way out of the airport, expect a drive of about 5 minutes.
You can expect the trip to take roughly 25 minutes on public transport.
Hang up the 'Do not disturb' sign and rest at a hotel near BLB. Here are a few options where you can take a load off after your flight from Rome to Panama City:
Forget about inconvenient public transport timetables or long cab queues. Grab a Marcos A. Gelabert International Airport rental car and let the journey unfold your way. Compare availability and rates from Thrifty, Avis and Alamo.
Avoid last-minute price surges. Reserving your ride three weeks ahead of your arrival at PAC will help you save.

Panama Pacifico Airport (BLB)

Hop off your flight from Rome to Panama City and head straight for your hotel or start exploring right away. The centre of Panama City is around 11 kilometres from Panama Pacifico Airport (BLB) and typically takes 20 minutes to reach by car.
Begin your journey without worrying about how to get to where you're going with a Panama Pacifico Airport rental car. Find your perfect set of wheels with trusted suppliers here like Sixt, Dollar and Thrifty.
If you're looking for a specific model or make, book your ride from BLB around one week ahead of your flight from Rome to Panama City. This gives you a better shot at getting your preferred car, as well as a better rate.

Best time to go to Panama City

It's time to pick your trip dates for your flight from Rome to Panama City. June is the busiest month to visit Panama City. If you like a quieter atmosphere, go in February.
Before locking in your Rome to Panama City tickets, think about what kind of weather works for you. March is the warmest month in Panama City, with temperatures ranging from 21ºC to 32ºC.
Search for cheap flights from Rome to Panama City in February if you'd rather travel when it's cooler. Temperatures are at their lowest then, ranging between 22ºC and 31ºC on average.

More about Panama City

Once you've booked your flight from Rome to Panama City, find a hotel that offers the right mix of comfort and location. Make one of these options your base for exploring Panama City:
Panama Canal Museum and Casco Viejo are a couple of major attractions to put on your Panama City must-do list. Continue your sightseeing adventures at Cinta Costera.

Explore more of Panama

You've visited Panama City, now it's time to explore other corners of Panama. Journey about 6 kilometres north to San Miguelito to check off its leading sights. From Iglesia Cristo Luz del Mundo to IDMJI SAN MIGUELITO and Iglesia Bautista Independiente Emanuel, there's plenty to keep you busy.
Juan Díaz is another essential stop in Panama and is around 11 kilometres north-east of Panama City. No journey is complete without a visit to Malecon Costa Del Este, El Patio Human Friendly and Parque Los Robles Sur.