Cheap Flights from Raleigh / Durham to Des Moines

Compare Raleigh / Durham to Des Moines flight deals

Find the cheapest month or even day of the year to fly to Des Moines

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Flight deals from Raleigh / Durham Airport to Des Moines Airport

Looking for a cheap last-minute deal or the best return flight from Raleigh / Durham Airport to Des Moines Airport? If you want to travel next month, return fares start from $524. Find the lowest prices on one-way and return tickets right here.

Des Moines.$524 per passenger.Departing Thu, 16 Apr, returning Mon, 20 Apr.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Raleigh / Durham on Thu, 16 Apr, arriving in Des Moines.Inbound indirect flight with Southwest Airlines, departs from Des Moines on Mon, 20 Apr, arriving in Raleigh / Durham.Price includes taxes and charges.From $524, select.

Des Moines.$541 per passenger.Departing Wed, 10 Jun, returning Wed, 17 Jun.Return flight with Delta.Outbound indirect flight with Delta, departs from Raleigh / Durham on Wed, 10 Jun, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 17 Jun, arriving in Raleigh / Durham.Price includes taxes and charges.From $541, select.

Des Moines.$579 per passenger.Departing Sun, 3 May, returning Wed, 6 May.Return flight with Delta.Outbound indirect flight with Delta, departs from Raleigh / Durham on Sun, 3 May, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 6 May, arriving in Raleigh / Durham.Price includes taxes and charges.From $579, select.

Des Moines.$695 per passenger.Departing Thu, 24 Sep, returning Mon, 5 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from Raleigh / Durham on Thu, 24 Sep, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Mon, 5 Oct, arriving in Raleigh / Durham.Price includes taxes and charges.From $695, select.

Des Moines.$832 per passenger.Departing Tue, 31 Mar, returning Sat, 4 Apr.Return flight with Delta.Outbound indirect flight with Delta, departs from Raleigh / Durham on Tue, 31 Mar, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Sat, 4 Apr, arriving in Raleigh / Durham.Price includes taxes and charges.From $832, select.

Des Moines.$1,635 per passenger.Departing Fri, 20 Mar, returning Tue, 24 Mar.Return flight with Delta.Outbound indirect flight with Delta, departs from Raleigh / Durham on Fri, 20 Mar, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Tue, 24 Mar, arriving in Raleigh / Durham.Price includes taxes and charges.From $1,635, select.

Find the cheapest month to fly from Raleigh / Durham to Des Moines

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Raleigh / Durham to Des Moines flights are currently cheapest in April.

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Raleigh / Durham to Des Moines: Alternative routes

Compare routes from Raleigh / Durham to Des Moines below. You may find an airport to fly into that's cheaper, faster, or easier than Des Moines.

Des Moines

8km from central Des Moines

ClosestCheapest

from $524

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Durham to Des Moines: Flight information

The things to know before you go.

Cheapest flight found	$524
Cheapest month to fly	April

Check out these Des Moines hotels

Ready to plan your stay? Other travellers rate these Des Moines hotels for cleanliness, service and location.

Des Lux Hotel

2.23 km from city centre

$291

Per night

Home2 Suites des Moines at Drake University

3.60 km from city centre

$187

Per night

Fairfield Inn & Suites des Moines Airport

9.26 km from city centre

$305

Per night

Des Lux Hotel

2.23 km from city centre

$291

Per night

Home2 Suites des Moines at Drake University

3.60 km from city centre

$187

Per night

Fairfield Inn & Suites des Moines Airport

9.26 km from city centre

$305

Per night

Explore top-rated hotels

Finding cheap flights from Raleigh / Durham to Des Moines: Frequently asked questions

How much are return flights from Raleigh / Durham to Des Moines?

The best price we found for a return flight from Raleigh / Durham to Des Moines is $524. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Raleigh / Durham to Des Moines?

Currently, there are no airlines that fly direct from Raleigh / Durham to Des Moines. But we found flights with one or more stops from $524.

How many flights are there a week from Raleigh / Durham to Des Moines?

As of March 2026, there are no flights flying from Raleigh / Durham to Des Moines.

When is the cheapest time to fly from Raleigh / Durham to Des Moines?

The cheapest month to fly from Raleigh / Durham to Des Moines is usually April.

Which upcoming date is cheapest to fly from Raleigh / Durham Airport to Des Moines Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Raleigh / Durham Airport to Des Moines Airport on Thursday, 16 April 2026.

Can I get a direct flight from Raleigh / Durham Airport to Des Moines Airport?

No airlines currently offer direct flights between Raleigh / Durham Airport and Des Moines Airport. Most routes have one or more stops.

How can I find the best flight deal to Des Moines?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Des Moines but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Des Moines?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Des Moines is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Raleigh / Durham Airport to Des Moines with?

Currently, Southwest Airlines offers the cheapest flight tickets to Des Moines.

Travelling from Raleigh-Durham International Airport (RDU) to Des Moines International Airport (DSM): what you need to know

Give yourself enough time to make your RDU to DSM flight. As a general rule, turn up two hours before international departures and an hour ahead for domestic flights.
You'll likely experience longer queues during popular months such as July. Arriving up to four hours ahead of an international flight and two hours for domestic departures is a good idea.
If you want to add a stop to your trip, simply uncheck 'Direct flights only' when searching for your ticket from Raleigh-Durham International Airport to Des Moines International Airport. Here are the top stopovers between RDU and DSM:
- Lambert-St. Louis International Airport
- Charlotte Douglas International Airport
- Hartsfield-Jackson Atlanta International Airport

How to find the cheapest flights from Raleigh-Durham International Airport (RDU) to Des Moines International Airport (DSM)

$317 is currently the best price for a one-way Raleigh-Durham International Airport to Des Moines International Airport flight. Return flights start at $524. These fares can change depending on demand.
To get your hands on cheap tickets from RDU to DSM, book early. Airlines generally offer lower prices when flights are first released.
The 'Whole month' search function shows you the cheapest flights from Raleigh-Durham International Airport to Des Moines International Airport throughout the month. It's an easy way to find a bargain if your travel dates aren't set in stone.
Save time looking for cheap flights from RDU to DSM by creating a Price Alert. You'll receive an email or notification through the app when a lower fare becomes available.
Select your ideal arrival and departure times, number of stops and airlines with the filters. Or sort your results by 'Cheapest' to find the best deals on flights from Raleigh-Durham International Airport to Des Moines International Airport.

Handy information about Raleigh-Durham International Airport (RDU)

Raleigh-Durham International Airport scores top marks for its on-time performance. 80.09% of flights that depart RDU land on time.
Raleigh-Durham International Airport is about 23 kilometres from central Durham. If you're driving, catching a cab or ride-sharing from the centre, it'll take you 20 minutes or so to get there, depending on the traffic.
You can expect a trip time of about 1 hour 10 minutes on public transport.
Have an early flight from Raleigh-Durham International Airport to Des Moines International Airport? Avoid rushing to the airport (and sneak in some extra snooze time) by picking one of these stays close to RDU:

Arriving at Des Moines International Airport (DSM)

Consider staying in a hotel close to DSM if you're taking a late Raleigh-Durham International Airport to Des Moines International Airport flight. Choose one of these accommodation options and avoid the hassle of a long transfer:
Say yes to new adventures by picking up a Des Moines International Airport rental car. Grab a set of wheels from Hertz, Enterprise or Alamo and explore beyond Des Moines's main sights.
To lock in the lowest rate, book your ride from Des Moines International Airport several weeks in advance. Prices typically increase closer to your date of travel.

Getting from Des Moines International Airport (DSM) to central Des Moines

DSM is located at 5800 Fleur Drive, Suite 201.
From Des Moines International Airport, Des Moines is approximately 10 kilometres away. It takes around 15 minutes to reach the centre by car.
It'll take around 45 minutes to get there by public transport.

When to fly to Des Moines International Airport (DSM)

It's time to work out your dates for your flight from Raleigh-Durham International Airport to Des Moines International Airport. July is the most popular month to visit Des Moines. If you're after a more low-key vibe, go in April.
When booking your flight from Raleigh-Durham International Airport to Des Moines International Airport, consider the kind of weather you like. July is the warmest month in Des Moines, with temperatures ranging from 15ºC to 31ºC.
Search for cheap tickets from RDU to DSM in January if you'd rather travel during cooler conditions. Temperatures are at their lowest around then, ranging between -13ºC and 2ºC on average.

Explore more of United States

Des Moines has its own special appeal, but there are so many other corners of United States you'll want to see. About 499 kilometres east of Des Moines, a visit to Chicago will keep you busy. Check out popular attractions like Millennium Park, Art Institute of Chicago and LandShark Beer Garden at Navy Pier.
If you want to check out another corner of United States, head for Milwaukee, about 499 kilometres east of Des Moines. Miller Park, Pabst Mansion and Milwaukee Public Museum are highlights.